Functional and structural insight into properdin control of complement alternative pathway amplification

Properdin (FP) is an essential positive regulator of the complement alternative pathway (AP) providing stabilization of the C3 and C5 convertases, but its oligomeric nature challenges structural analysis. We describe here a novel FP deficiency (E244K) caused by a single point mutation which results...

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Vydáno v:EMBO J
Hlavní autoři: Pedersen, Dennis V, Roumenina, Lubka, Jensen, Rasmus K, Gadeberg, Trine AF, Marinozzi, Chiara, Picard, Capucine, Rybkine, Tania, Thiel, Steffen, Sørensen, Uffe BS, Stover, Cordula, Fremeaux‐Bacchi, Veronique, Andersen, Gregers R
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2017
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Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5391138/
https://ncbi.nlm.nih.gov/pubmed/28264884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201696173
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