Novel decay dynamics revealed for virus-mediated drug activation in cytomegalovirus infection

Human cytomegalovirus (CMV) infection is a substantial cause of morbidity and mortality in immunocompromised hosts and globally is one of the most important congenital infections. The nucleoside analogue ganciclovir (GCV), which requires initial phosphorylation by the viral UL97 kinase, is the mains...

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Bibliographic Details
Published in:PLoS Pathog
Main Authors: Rose, Jessica, Emery, Vincent C., Kumar, Deepali, Asberg, Anders, Hartmann, Anders, Jardine, Alan G., Bignamini, Angelo A., Humar, Atul, Neumann, Avidan U.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2017
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5391089/
https://ncbi.nlm.nih.gov/pubmed/28406982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006299
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