Novel decay dynamics revealed for virus-mediated drug activation in cytomegalovirus infection

Human cytomegalovirus (CMV) infection is a substantial cause of morbidity and mortality in immunocompromised hosts and globally is one of the most important congenital infections. The nucleoside analogue ganciclovir (GCV), which requires initial phosphorylation by the viral UL97 kinase, is the mains...

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Publicado en:PLoS Pathog
Main Authors: Rose, Jessica, Emery, Vincent C., Kumar, Deepali, Asberg, Anders, Hartmann, Anders, Jardine, Alan G., Bignamini, Angelo A., Humar, Atul, Neumann, Avidan U.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2017
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5391089/
https://ncbi.nlm.nih.gov/pubmed/28406982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006299
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