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Low pH(o) boosts burst firing and catecholamine release by blocking TASK‐1 and BK channels while preserving Cav1 channels in mouse chromaffin cells

KEY POINTS: Mouse chromaffin cells (MCCs) generate spontaneous burst‐firing that causes large increases of Ca(2+)‐dependent catecholamine release, and is thus a key mechanism for regulating the functions of MCCs. With the aim to uncover a physiological role for burst‐firing we investigated the effec...

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Publicat a:J Physiol
Autors principals: Guarina, Laura, Vandael, David H. F., Carabelli, Valentina, Carbone, Emilio
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2017
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5390891/
https://ncbi.nlm.nih.gov/pubmed/28026020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP273735
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