Loss of Cav1.3 Channels Reveals the Critical Role of L-Type and BK Channel Coupling in Pacemaking Mouse Adrenal Chromaffin Cells

We studied wild-type (WT) and Cav1.3(−/−) mouse chromaffin cells (MCCs) with the aim to determine the isoform of L-type Ca(2+) channel (LTCC) and BK channels that underlie the pacemaker current controlling spontaneous firing. Most WT-MCCs (80%) were spontaneously active (1.5 Hz) and highly sensitive...

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Published in:J Neurosci
Main Authors: Marcantoni, Andrea, Vandael, David H. F., Mahapatra, Satyajit, Carabelli, Valentina, Sinnegger-Brauns, Martina J., Striessnig, Joerg, Carbone, Emilio
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2010
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6633011/
https://ncbi.nlm.nih.gov/pubmed/20071512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4961-09.2010
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