Reduced availability of voltage-gated sodium channels by depolarization or blockade by tetrodotoxin boosts burst firing and catecholamine release in mouse chromaffin cells

Action potential (AP) firing in mouse chromaffin cells (MCCs) is mainly sustained by Cav1.3 L-type channels that drive BK and SK currents and regulate the pacemaking cycle. As secretory units, CCs optimally recruit Ca(2+) channels when stimulated, a process potentially dependent on the modulation of...

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Vydáno v:J Physiol
Hlavní autoři: Vandael, David H F, Ottaviani, Matteo M, Legros, Christian, Lefort, Claudie, Guérineau, Nathalie C, Allio, Arianna, Carabelli, Valentina, Carbone, Emilio
Médium: Artigo
Jazyk:Inglês
Vydáno: BlackWell Publishing Ltd 2015
Témata:
Neuroscience: Cellular/Molecular
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4398529/
https://ncbi.nlm.nih.gov/pubmed/25620605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2014.283374
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