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Acute ER stress regulates amyloid precursor protein processing through ubiquitin-dependent degradation
Beta-amyloid (Aβ), a major pathological hallmark of Alzheimer's disease (AD), is derived from amyloid precursor protein (APP) through sequential cleavage by β-secretase and γ-secretase enzymes. APP is an integral membrane protein, and plays a key role in the pathogenesis of AD; however, the bio...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5390087/ https://ncbi.nlm.nih.gov/pubmed/25740315 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep08805 |
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