Pin1 Modulates ERα Levels in Breast Cancer through Inhibition of Phosphorylation-dependent Ubiquitination and Degradation

Estrogen receptor-alpha (ERα) is an important biomarker used to classify and direct therapy decisions in breast cancer. Both ERα protein and its transcript, ESR1, are used to predict response to tamoxifen therapy, yet certain tumors have discordant levels of ERα protein and ESR1, which is currently...

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Autores principales: Rajbhandari, Prashant, Schalper, Kurt A., Solodin, Natalia M., Ellison-Zelski, Stephanie J., Lu, Kun Ping, Rimm, David L., Alarid, Elaine T.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3815749/
https://ncbi.nlm.nih.gov/pubmed/23542176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.78
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