The trans-Sialidase from Trypanosoma cruzi Induces Thrombocytopenia during Acute Chagas' Disease by Reducing the Platelet Sialic Acid Contents

Strong thrombocytopenia is observed during acute infection with Trypanosoma cruzi, the parasitic protozoan agent of American trypanosomiasis or Chagas' disease. The parasite sheds trans-sialidase, an enzyme able to mobilize the sialyl residues on cell surfaces, which is distributed in blood and...

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Опубликовано в: :Infect Immun
Главные авторы: Tribulatti, María Virginia, Mucci, Juan, Van Rooijen, Nico, Leguizamón, María Susana, Campetella, Oscar
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology (ASM) 2005
Предметы:
Fungal and Parasitic Infections
Online-ссылка:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC538983/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15618155/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.73.1.201-207.2005
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