Trypanosoma cruzi trans-Sialidase Prevents Elicitation of Th1 Cell Response via Interleukin 10 and Downregulates Th1 Effector Cells

The trans-sialidases (TSs) from Trypanosoma cruzi, the agent of Chagas disease, are virulence factors shed to the bloodstream that induce strong alterations in the immune system. Here, we report that both enzymatically active TS (aTS) and its lectinlike isoform (iTS) disturb CD4 T cell physiology, i...

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Bibliografske podrobnosti
izdano v:Infect Immun
Main Authors: Ruiz Díaz, Pablo, Mucci, Juan, Meira, María Ana, Bogliotti, Yanina, Musikant, Daniel, Leguizamón, María Susana, Campetella, Oscar
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2015
Teme:
Fungal and Parasitic Infections
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4399057/
https://ncbi.nlm.nih.gov/pubmed/25754197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00031-15
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