Trypanosoma cruzi trans-Sialidase Prevents Elicitation of Th1 Cell Response via Interleukin 10 and Downregulates Th1 Effector Cells

The trans-sialidases (TSs) from Trypanosoma cruzi, the agent of Chagas disease, are virulence factors shed to the bloodstream that induce strong alterations in the immune system. Here, we report that both enzymatically active TS (aTS) and its lectinlike isoform (iTS) disturb CD4 T cell physiology, i...

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Detalhes bibliográficos
Publicado no:Infect Immun
Main Authors: Ruiz Díaz, Pablo, Mucci, Juan, Meira, María Ana, Bogliotti, Yanina, Musikant, Daniel, Leguizamón, María Susana, Campetella, Oscar
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Fungal and Parasitic Infections
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4399057/
https://ncbi.nlm.nih.gov/pubmed/25754197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00031-15
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