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Structural and biochemical differences between the Notch and the amyloid precursor protein transmembrane domains
γ-Secretase cleavage of the Notch receptor transmembrane domain is a critical signaling event for various cellular processes. Efforts to develop inhibitors of γ-secretase cleavage of the amyloid-β precursor C99 protein as potential Alzheimer’s disease therapeutics have been confounded by toxicity re...
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| Publicado no: | Sci Adv |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Association for the Advancement of Science
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5389784/ https://ncbi.nlm.nih.gov/pubmed/28439555 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1602794 |
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