In vivo modification of tRNA with an artificial nucleobase leads to full disease remission in an animal model of multiple sclerosis

Queuine is a modified pyrrolopyrimidine nucleobase derived exclusively from bacteria. It post-transcriptionally replaces guanine 34 in transfer RNA isoacceptors for Asp, Asn, His and Tyr, in almost all eukaryotic organisms, through the activity of the ancient tRNA guanine transglycosylase (TGT) enzy...

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Bibliographische Detailangaben
Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Varghese, Sreeja, Cotter, Michelle, Chevot, Franciane, Fergus, Claire, Cunningham, Colm, Mills, Kingston H., Connon, Stephen J., Southern, John M., Kelly, Vincent P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2017
Schlagworte:
RNA
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5389723/
https://ncbi.nlm.nih.gov/pubmed/28204548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw847
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