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In vivo modification of tRNA with an artificial nucleobase leads to full disease remission in an animal model of multiple sclerosis
Queuine is a modified pyrrolopyrimidine nucleobase derived exclusively from bacteria. It post-transcriptionally replaces guanine 34 in transfer RNA isoacceptors for Asp, Asn, His and Tyr, in almost all eukaryotic organisms, through the activity of the ancient tRNA guanine transglycosylase (TGT) enzy...
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| 出版年: | Nucleic Acids Res |
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| 主要な著者: | , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Oxford University Press
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5389723/ https://ncbi.nlm.nih.gov/pubmed/28204548 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw847 |
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