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In vivo modification of tRNA with an artificial nucleobase leads to full disease remission in an animal model of multiple sclerosis
Queuine is a modified pyrrolopyrimidine nucleobase derived exclusively from bacteria. It post-transcriptionally replaces guanine 34 in transfer RNA isoacceptors for Asp, Asn, His and Tyr, in almost all eukaryotic organisms, through the activity of the ancient tRNA guanine transglycosylase (TGT) enzy...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Nucleic Acids Res |
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| Κύριοι συγγραφείς: | , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Oxford University Press
2017
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5389723/ https://ncbi.nlm.nih.gov/pubmed/28204548 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw847 |
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