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sCNAphase: using haplotype resolved read depth to genotype somatic copy number alterations from low cellularity aneuploid tumors

Accurate identification of copy number alterations is an essential step in understanding the events driving tumor progression. While a variety of algorithms have been developed to use high-throughput sequencing data to profile copy number changes, no tool is able to reliably characterize ploidy and...

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Dettagli Bibliografici
Pubblicato in:Nucleic Acids Res
Autori principali: Chen, Wenhan, Robertson, Alan J., Ganesamoorthy, Devika, Coin, Lachlan J.M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5389684/
https://ncbi.nlm.nih.gov/pubmed/27903916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw1086
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