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GROM-RD: resolving genomic biases to improve read depth detection of copy number variants

Amplifications or deletions of genome segments, known as copy number variants (CNVs), have been associated with many diseases. Read depth analysis of next-generation sequencing (NGS) is an essential method of detecting CNVs. However, genome read coverage is frequently distorted by various biases of...

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Detalhes bibliográficos
Publicado no:PeerJ
Main Authors: Smith, Sean D., Kawash, Joseph K., Grigoriev, Andrey
Formato: Artigo
Idioma:Inglês
Publicado em: PeerJ Inc. 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4369336/
https://ncbi.nlm.nih.gov/pubmed/25802807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7717/peerj.836
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