Microhomology-mediated end joining is activated in irradiated human cells due to phosphorylation-dependent formation of the XRCC1 repair complex

Microhomology-mediated end joining (MMEJ), an error-prone pathway for DNA double-strand break (DSB) repair, is implicated in genomic rearrangement and oncogenic transformation; however, its contribution to repair of radiation-induced DSBs has not been characterized. We used recircularization of a li...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Dutta, Arijit, Eckelmann, Bradley, Adhikari, Sanjay, Ahmed, Kazi Mokim, Sengupta, Shiladitya, Pandey, Arvind, Hegde, Pavana M., Tsai, Miaw-Sheue, Tainer, John A., Weinfeld, Michael, Hegde, Muralidhar L., Mitra, Sankar
Format: Artigo
Language:Inglês
Published: Oxford University Press 2017
Subjects:
Genome Integrity, Repair and Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5389627/
https://ncbi.nlm.nih.gov/pubmed/27994036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw1262
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