The Second-Generation Maturation Inhibitor GSK3532795 Maintains Potent Activity Toward HIV Protease Inhibitor–Resistant Clinical Isolates

BACKGROUND: Protease inhibitor (PI)-resistant HIV-1 isolates with primary substitutions in protease (PR) and secondary substitutions in Gag could potentially exhibit cross-resistance to maturation inhibitors. We evaluated the second-generation maturation inhibitor, GSK3532795, for activity toward cl...

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Detalhes bibliográficos
Publicado no:J Acquir Immune Defic Syndr
Main Authors: Ray, Neelanjana, Li, Tianbo, Lin, Zeyu, Protack, Tricia, van Ham, Petronella Maria, Hwang, Carey, Krystal, Mark, Nijhuis, Monique, Lataillade, Max, Dicker, Ira
Formato: Artigo
Idioma:Inglês
Publicado em: JAIDS Journal of Acquired Immune Deficiency Syndromes 2017
Assuntos:
Clinical Science
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5389583/
https://ncbi.nlm.nih.gov/pubmed/28234686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAI.0000000000001304
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