Mechanistic Studies and Modeling Reveal the Origin of Differential Inhibition of Gag Polymorphic Viruses by HIV-1 Maturation Inhibitors

HIV-1 maturation inhibitors (MIs) disrupt the final step in the HIV-1 protease-mediated cleavage of the Gag polyprotein between capsid p24 capsid (CA) and spacer peptide 1 (SP1), leading to the production of infectious virus. BMS-955176 is a second generation MI with improved antiviral activity towa...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Lin, Zeyu, Cantone, Joseph, Lu, Hao, Nowicka-Sans, Beata, Protack, Tricia, Yuan, Tian, Yang, Hong, Liu, Zheng, Drexler, Dieter, Regueiro-Ren, Alicia, Meanwell, Nicholas A., Cockett, Mark, Krystal, Mark, Lataillade, Max, Dicker, Ira B.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5125710/
https://ncbi.nlm.nih.gov/pubmed/27893830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005990
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