A structure–function analysis of the yeast Elg1 protein reveals the importance of PCNA unloading in genome stability maintenance

The sliding clamp, PCNA, plays a central role in DNA replication and repair. In the moving replication fork, PCNA is present at the leading strand and at each of the Okazaki fragments that are formed on the lagging strand. PCNA enhances the processivity of the replicative polymerases and provides a...

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Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Shemesh, Keren, Sebesta, Marek, Pacesa, Martin, Sau, Soumitra, Bronstein, Alex, Parnas, Oren, Liefshitz, Batia, Venclovas, Česlovas, Krejci, Lumir, Kupiec, Martin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2017
Schlagworte:
Genome Integrity, Repair and Replication
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5389545/
https://ncbi.nlm.nih.gov/pubmed/28108661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw1348
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