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Access to PCNA by Srs2 and Elg1 Controls the Choice between Alternative Repair Pathways in Saccharomyces cerevisiae

During DNA replication, stalling can occur when the replicative DNA polymerases encounter lesions or hard-to replicate regions. Under these circumstances, the processivity factor PCNA gets ubiquitylated at lysine 164, inducing the DNA damage tolerance (DDT) mechanisms that can bypass lesions encount...

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Publicado en:mBio
Main Authors: Arbel, Matan, Bronstein, Alex, Sau, Soumitra, Liefshitz, Batia, Kupiec, Martin
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7403780/
https://ncbi.nlm.nih.gov/pubmed/32371600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00705-20
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