Binding Site of the Bridged Macrolides in the Escherichia coli Ribosome

Ketolides represent the latest group of macrolide antibiotics. Tight binding of ketolides to the ribosome appears to correlate with the presence of an extended alkyl-aryl side chain. Recently developed 6,11-bridged bicyclic ketolides extend the spectrum of platforms used to generate new potent macro...

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Hlavní autoři: Xiong, Liqun, Korkhin, Yakov, Mankin, Alexander S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2005
Témata:
Mechanisms of Action: Physiological Effects
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC538896/
https://ncbi.nlm.nih.gov/pubmed/15616307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.1.281-288.2005
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