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Binding Site of the Bridged Macrolides in the Escherichia coli Ribosome

Ketolides represent the latest group of macrolide antibiotics. Tight binding of ketolides to the ribosome appears to correlate with the presence of an extended alkyl-aryl side chain. Recently developed 6,11-bridged bicyclic ketolides extend the spectrum of platforms used to generate new potent macro...

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Bibliografiske detaljer
Main Authors: Xiong, Liqun, Korkhin, Yakov, Mankin, Alexander S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2005
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC538896/
https://ncbi.nlm.nih.gov/pubmed/15616307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.1.281-288.2005
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