Binding Site of Macrolide Antibiotics on the Ribosome: New Resistance Mutation Identifies a Specific Interaction of Ketolides with rRNA

Macrolides represent a clinically important class of antibiotics that block protein synthesis by interacting with the large ribosomal subunit. The macrolide binding site is composed primarily of rRNA. However, the mode of interaction of macrolides with rRNA and the exact location of the drug binding...

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Detalhes bibliográficos

Publicado no:	J Bacteriol
Principais autores:	Garza-Ramos, Georgina, Xiong, Liqun, Zhong, Ping, Mankin, Alexander
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2001
Assuntos:	Genetics and Molecular Biology
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC95531/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11698379/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JB.183.23.6898-6907.2001
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