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Binding Site of Macrolide Antibiotics on the Ribosome: New Resistance Mutation Identifies a Specific Interaction of Ketolides with rRNA

Macrolides represent a clinically important class of antibiotics that block protein synthesis by interacting with the large ribosomal subunit. The macrolide binding site is composed primarily of rRNA. However, the mode of interaction of macrolides with rRNA and the exact location of the drug binding...

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Autori principali: Garza-Ramos, Georgina, Xiong, Liqun, Zhong, Ping, Mankin, Alexander
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2001
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC95531/
https://ncbi.nlm.nih.gov/pubmed/11698379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.183.23.6898-6907.2001
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