Antisense Phosphorodiamidate Morpholino Oligomer Length and Target Position Effects on Gene-Specific Inhibition in Escherichia coli

Phosphorodiamidate morpholino oligomers (PMOs) are synthetic DNA analogs that inhibit gene expression in a sequence-dependent manner. PMOs of various lengths (7 to 20 bases) were tested for inhibition of luciferase expression in Escherichia coli. Shorter PMOs generally inhibited luciferase greater t...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Deere, Jesse, Iversen, Pat, Geller, Bruce L.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2005
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Mechanisms of Action: Physiological Effects
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC538888/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15616302/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.49.1.249-255.2005
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