Gene-Specific Effects of Antisense Phosphorodiamidate Morpholino Oligomer-Peptide Conjugates on Escherichia coli and Salmonella enterica Serovar Typhimurium in Pure Culture and in Tissue Culture

The objective was to improve efficacy of antisense phosphorodiamidate morpholino oligomers (PMOs) by improving their uptake into bacterial cells. Four different bacterium-permeating peptides, RFFRFFRFFXB, RTRTRFLRRTXB, RXXRXXRXXB, and KFFKFFKFFKXB (X is 6-aminohexanoic acid and B is β-alanine), were...

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Autores principales: Tilley, Lucas D., Hine, Orion S., Kellogg, Jill A., Hassinger, Jed N., Weller, Dwight D., Iversen, Patrick L., Geller, Bruce L.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2006
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Mechanisms of Action: Physiological Effects
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1538669/
https://ncbi.nlm.nih.gov/pubmed/16870773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01286-05
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