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Plasmodium falciparum K13 Mutations Differentially Impact Ozonide Susceptibility and Parasite Fitness In Vitro

The emergence and spread in Southeast Asia of Plasmodium falciparum resistance to artemisinin (ART) derivatives, the cornerstone of first-line artemisinin-based combination therapies (ACTs), underscore the urgent need to identify suitable replacement drugs. Discovery and development efforts have ide...

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Detalhes bibliográficos
Publicado no:mBio
Main Authors: Straimer, Judith, Gnädig, Nina F., Stokes, Barbara H., Ehrenberger, Michelle, Crane, Audrey A., Fidock, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5388803/
https://ncbi.nlm.nih.gov/pubmed/28400526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00172-17
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