K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates

The emergence of artemisinin resistance in Southeast Asia imperils efforts to reduce the global malaria burden. We genetically modified the Plasmodium falciparum K13 locus using zinc-finger nucleases and measured ring-stage survival rates after drug exposure in vitro; these rates correlate with para...

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Detalhes bibliográficos
Publicado no:Science
Main Authors: Straimer, Judith, Gnädig, Nina F., Witkowski, Benoit, Amaratunga, Chanaki, Duru, Valentine, Ramadani, Arba Pramundita, Dacheux, Mélanie, Khim, Nimol, Zhang, Lei, Lam, Stephen, Gregory, Philip D., Urnov, Fyodor D., Mercereau-Puijalon, Odile, Benoit-Vical, Françoise, Fairhurst, Rick M., Ménard, Didier, Fidock, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4349400/
https://ncbi.nlm.nih.gov/pubmed/25502314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1260867
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