K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates

The emergence of artemisinin resistance in Southeast Asia imperils efforts to reduce the global malaria burden. We genetically modified the Plasmodium falciparum K13 locus using zinc-finger nucleases and measured ring-stage survival rates after drug exposure in vitro; these rates correlate with para...

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Foilsithe in:Science
Main Authors: Straimer, Judith, Gnädig, Nina F., Witkowski, Benoit, Amaratunga, Chanaki, Duru, Valentine, Ramadani, Arba Pramundita, Dacheux, Mélanie, Khim, Nimol, Zhang, Lei, Lam, Stephen, Gregory, Philip D., Urnov, Fyodor D., Mercereau-Puijalon, Odile, Benoit-Vical, Françoise, Fairhurst, Rick M., Ménard, Didier, Fidock, David A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2014
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4349400/
https://ncbi.nlm.nih.gov/pubmed/25502314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1260867
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