Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness

The emergence of mutant K13-mediated artemisinin (ART) resistance in Plasmodium falciparum malaria parasites has led to widespread treatment failures across Southeast Asia. In Africa, K13-propeller genotyping confirms the emergence of the R561H mutation in Rwanda and highlights the continuing domina...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Stokes, Barbara H, Dhingra, Satish K, Rubiano, Kelly, Mok, Sachel, Straimer, Judith, Gnädig, Nina F, Deni, Ioanna, Schindler, Kyra A, Bath, Jade R, Ward, Kurt E, Striepen, Josefine, Yeo, Tomas, Ross, Leila S, Legrand, Eric, Ariey, Frédéric, Cunningham, Clark H, Souleymane, Issa M, Gansané, Adama, Nzoumbou-Boko, Romaric, Ndayikunda, Claudette, Kabanywanyi, Abdunoor M, Uwimana, Aline, Smith, Samuel J, Kolley, Olimatou, Ndounga, Mathieu, Warsame, Marian, Leang, Rithea, Nosten, François, Anderson, Timothy JC, Rosenthal, Philip J, Ménard, Didier, Fidock, David A
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2021
Assuntos:
Epidemiology and Global Health
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8321553/
https://ncbi.nlm.nih.gov/pubmed/34279219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.66277
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