Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness

The emergence of mutant K13-mediated artemisinin (ART) resistance in Plasmodium falciparum malaria parasites has led to widespread treatment failures across Southeast Asia. In Africa, K13-propeller genotyping confirms the emergence of the R561H mutation in Rwanda and highlights the continuing domina...

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Publicado en:eLife
Autores principales: Stokes, Barbara H, Dhingra, Satish K, Rubiano, Kelly, Mok, Sachel, Straimer, Judith, Gnädig, Nina F, Deni, Ioanna, Schindler, Kyra A, Bath, Jade R, Ward, Kurt E, Striepen, Josefine, Yeo, Tomas, Ross, Leila S, Legrand, Eric, Ariey, Frédéric, Cunningham, Clark H, Souleymane, Issa M, Gansané, Adama, Nzoumbou-Boko, Romaric, Ndayikunda, Claudette, Kabanywanyi, Abdunoor M, Uwimana, Aline, Smith, Samuel J, Kolley, Olimatou, Ndounga, Mathieu, Warsame, Marian, Leang, Rithea, Nosten, François, Anderson, Timothy JC, Rosenthal, Philip J, Ménard, Didier, Fidock, David A
Formato: Artigo
Lenguaje:Inglês
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Epidemiology and Global Health
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8321553/
https://ncbi.nlm.nih.gov/pubmed/34279219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.66277
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