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Engineering of a synthetic quadrastable gene network to approach Waddington landscape and cell fate determination

The process of cell fate determination has been depicted intuitively as cells travelling and resting on a rugged landscape, which has been probed by various theoretical studies. However, few studies have experimentally demonstrated how underlying gene regulatory networks shape the landscape and henc...

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Bibliografske podrobnosti
izdano v:eLife
Main Authors: Wu, Fuqing, Su, Ri-Qi, Lai, Ying-Cheng, Wang, Xiao
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5388541/
https://ncbi.nlm.nih.gov/pubmed/28397688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.23702
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