p27(Kip1) promotes invadopodia turnover and invasion through the regulation of the PAK1/Cortactin pathway

p27(Kip1) (p27) is a cyclin-CDK inhibitor and negative regulator of cell proliferation. p27 also controls other cellular processes including migration and cytoplasmic p27 can act as an oncogene. Furthermore, cytoplasmic p27 promotes invasion and metastasis, in part by promoting epithelial to mesench...

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Pubblicato in:eLife
Autori principali: Jeannot, Pauline, Nowosad, Ada, Perchey, Renaud T, Callot, Caroline, Bennana, Evangeline, Katsube, Takanori, Mayeux, Patrick, Guillonneau, François, Manenti, Stéphane, Besson, Arnaud
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2017
Soggetti:
Cancer Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5388532/
https://ncbi.nlm.nih.gov/pubmed/28287395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.22207
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