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p27(Kip1) promotes invadopodia turnover and invasion through the regulation of the PAK1/Cortactin pathway
p27(Kip1) (p27) is a cyclin-CDK inhibitor and negative regulator of cell proliferation. p27 also controls other cellular processes including migration and cytoplasmic p27 can act as an oncogene. Furthermore, cytoplasmic p27 promotes invasion and metastasis, in part by promoting epithelial to mesench...
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| Veröffentlicht in: | eLife |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
eLife Sciences Publications, Ltd
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5388532/ https://ncbi.nlm.nih.gov/pubmed/28287395 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.22207 |
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