p27(Kip1) promotes invadopodia turnover and invasion through the regulation of the PAK1/Cortactin pathway

p27(Kip1) (p27) is a cyclin-CDK inhibitor and negative regulator of cell proliferation. p27 also controls other cellular processes including migration and cytoplasmic p27 can act as an oncogene. Furthermore, cytoplasmic p27 promotes invasion and metastasis, in part by promoting epithelial to mesench...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Jeannot, Pauline, Nowosad, Ada, Perchey, Renaud T, Callot, Caroline, Bennana, Evangeline, Katsube, Takanori, Mayeux, Patrick, Guillonneau, François, Manenti, Stéphane, Besson, Arnaud
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Cancer Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5388532/
https://ncbi.nlm.nih.gov/pubmed/28287395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.22207
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