The phosphatase Shp1 interacts with and dephosphorylates cortactin to inhibit invadopodia function

BACKGROUND: Invadopodia are actin-based cell-membrane protrusions associated with the extracellular matrix degradation accompanying cancer invasion. The elucidation of the molecular mechanisms leading to invadopodia formation and activity is central for the prevention of tumor spreading and growth....

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Cell Commun Signal
Main Authors: Varone, Alessia, Amoruso, Chiara, Monti, Marcello, Patheja, Manpreet, Greco, Adelaide, Auletta, Luigi, Zannetti, Antonella, Corda, Daniela
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2021
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8176763/
https://ncbi.nlm.nih.gov/pubmed/34088320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-021-00747-6
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