Effects of the RGD loop and C-terminus of rhodostomin on regulating integrin αIIbβ3 recognition

Rhodostomin (Rho) is a medium disintegrin containing a (48)PRGDMP motif. We here showed that Rho proteins with P48A, M52W, and P53N mutations can selectively inhibit integrin αIIbβ3. To study the roles of the RGD loop and C-terminal region in disintegrins, we expressed Rho (48)PRGDMP and (48)ARGDWN...

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Dettagli Bibliografici
Pubblicato in:PLoS One
Autori principali: Chang, Yao-Tsung, Shiu, Jia-Hau, Huang, Chun-Hao, Chen, Yi-Chun, Chen, Chiu-Yueh, Chang, Yung-Sheng, Chuang, Woei-Jer
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5388508/
https://ncbi.nlm.nih.gov/pubmed/28399159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0175321
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