Structural Insight into Integrin Recognition and Anticancer Activity of Echistatin

Echistatin (Ech) is a short disintegrin with a long <sup>42</sup>NPHKGPAT C-terminal tail. We determined the 3-D structure of Ech by X-ray crystallography. Superimposition of the structures of chains A and B showed conformational differences in their RGD loops and C-termini. The chain A...

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Detalhes bibliográficos
Main Authors: Yi-Chun Chen, Yao-Tsung Chang, Chiu-Yueh Chen, Jia-Hau Shiu, Chun-Ho Cheng, Chun-Hao Huang, Ju-Fei Chen, Woei-Jer Chuang
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2020-11-01
Colecção:Toxins
Assuntos:
echistatin
disintegrins
crystal structure
cancer cell migration
HUVEC proliferation
anticancer drug design
Acesso em linha:https://www.mdpi.com/2072-6651/12/11/709
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