Effect of P to A Mutation of the N-Terminal Residue Adjacent to the Rgd Motif on Rhodostomin: Importance of Dynamics in Integrin Recognition

Rhodostomin (Rho) is an RGD protein that specifically inhibits integrins. We found that Rho mutants with the P48A mutation 4.4–11.5 times more actively inhibited integrin α5β1. Structural analysis showed that they have a similar 3D conformation for the RGD loop. Docking analysis also showed no diffe...

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Bibliografiska uppgifter
Huvudupphovsmän: Shiu, Jia-Hau, Chen, Chiu-Yueh, Chen, Yi-Chun, Chang, Yao-Tsung, Chang, Yung-Sheng, Huang, Chun-Hao, Chuang, Woei-Jer
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2012
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3251565/
https://ncbi.nlm.nih.gov/pubmed/22238583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0028833
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