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A water-mediated allosteric network governs activation of Aurora kinase A
The catalytic activity of many protein kinases is controlled by conformational changes of a conserved Asp-Phe-Gly (DFG) motif. We used an infrared probe to track the DFG motif of the mitotic kinase Aurora A (AurA) and found that allosteric activation by the spindle-associated protein Tpx2 involves a...
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| 發表在: | Nat Chem Biol |
|---|---|
| Main Authors: | , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2017
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5388450/ https://ncbi.nlm.nih.gov/pubmed/28166210 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2296 |
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