Phosphorylation-specific status of RNAi triggers in pharmacokinetic and biodistribution analyses

The RNA interference (RNAi)-based therapeutic ARC-520 for chronic hepatitis B virus (HBV) infection consists of a melittin-derived peptide conjugated to N-acetylgalactosamine for hepatocyte targeting and endosomal escape, and cholesterol-conjugated RNAi triggers, which together result in HBV gene si...

詳細記述

保存先:
書誌詳細
出版年:Nucleic Acids Res
主要な著者: Trubetskoy, Vladimir S., Griffin, Jacob B., Nicholas, Anthony L., Nord, Eric M., Xu, Zhao, Peterson, Ryan M., Wooddell, Christine I., Rozema, David B., Wakefield, Darren H., Lewis, David L., Kanner, Steven B.
フォーマット: Artigo
言語:Inglês
出版事項: Oxford University Press 2017
主題:
RNA
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5388421/
https://ncbi.nlm.nih.gov/pubmed/28180327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw828
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