Phosphorylation-specific status of RNAi triggers in pharmacokinetic and biodistribution analyses

The RNA interference (RNAi)-based therapeutic ARC-520 for chronic hepatitis B virus (HBV) infection consists of a melittin-derived peptide conjugated to N-acetylgalactosamine for hepatocyte targeting and endosomal escape, and cholesterol-conjugated RNAi triggers, which together result in HBV gene si...

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Dettagli Bibliografici
Pubblicato in:Nucleic Acids Res
Autori principali: Trubetskoy, Vladimir S., Griffin, Jacob B., Nicholas, Anthony L., Nord, Eric M., Xu, Zhao, Peterson, Ryan M., Wooddell, Christine I., Rozema, David B., Wakefield, Darren H., Lewis, David L., Kanner, Steven B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2017
Soggetti:
RNA
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5388421/
https://ncbi.nlm.nih.gov/pubmed/28180327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw828
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