Phosphorylation-specific status of RNAi triggers in pharmacokinetic and biodistribution analyses

The RNA interference (RNAi)-based therapeutic ARC-520 for chronic hepatitis B virus (HBV) infection consists of a melittin-derived peptide conjugated to N-acetylgalactosamine for hepatocyte targeting and endosomal escape, and cholesterol-conjugated RNAi triggers, which together result in HBV gene si...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Trubetskoy, Vladimir S., Griffin, Jacob B., Nicholas, Anthony L., Nord, Eric M., Xu, Zhao, Peterson, Ryan M., Wooddell, Christine I., Rozema, David B., Wakefield, Darren H., Lewis, David L., Kanner, Steven B.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
RNA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5388421/
https://ncbi.nlm.nih.gov/pubmed/28180327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw828
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