Creation of an immunodeficient HLA-transgenic mouse (HUMAMICE) and functional validation of human immunity after transfer of HLA-matched human cells

Research on human immunology has been hindered by the lack of optimal small animal models, given that the protective immune responses of human and non-human species show significant differences. However, due to ethical constraints[1] and the high cost of clinical trials, it is urgent to improve the...

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Udgivet i:PLoS One
Main Authors: Zeng, Yang, Liu, Bingrun, Rubio, Marie-Thérèse, Wang, Xinyue, Ojcius, David M., Tang, Ruoping, Durrbach, Antoine, Ru, Zhitao, Zhou, Yusen, Lone, Yu-Chun
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5388326/
https://ncbi.nlm.nih.gov/pubmed/28399128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0173754
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