Development of a Humanized HLA-A2.1/DP4 Transgenic Mouse Model and the Use of This Model to Map HLA-DP4-Restricted Epitopes of HBV Envelope Protein

A new homozygous humanized transgenic mouse strain, HLA-A2.1(+/+)HLA-DP4(+/+) hCD4(+/+)mCD4(−/−)IAβ(−/−)β2m(−/−) (HLA-A2/DP4), was obtained by crossing the previously characterized HLA-A2(+/+)β2m(−/−) (A2) mouse and our previously created HLA-DP4(+/+) hCD4(+/+)mCD4(−/−)IAβ(−/−) (DP4) mouse. We confi...

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Bibliographic Details
Main Authors: Ru, Zhitao, Xiao, Wenjun, Pajot, Anthony, Kou, Zhihua, Sun, Shihui, Maillere, Bernard, Zhao, Guangyu, Ojcius, David M., Lone, Yu-chun, Zhou, Yusen
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3293898/
https://ncbi.nlm.nih.gov/pubmed/22403638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0032247
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