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Proteasome-Mediated Degradation of Cotranslationally Damaged Proteins Involves Translation Elongation Factor 1A

Rad23 and Rpn10 play synergistic roles in the recognition of ubiquitinated proteins by the proteasome, and loss of both proteins causes growth and proteolytic defects. However, the physiological targets of Rad23 and Rpn10 have not been well defined. We report that rad23Δ rpn10Δ is unable to grow in...

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Autori principali: Chuang, Show-Mei, Chen, Li, Lambertson, David, Anand, Monika, Kinzy, Terri Goss, Madura, Kiran
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2005
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC538794/
https://ncbi.nlm.nih.gov/pubmed/15601860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.1.403-413.2005
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