Evidence That Eukaryotic Translation Elongation Factor 1A (eEF1A) Binds the Gcn2 Protein C Terminus and Inhibits Gcn2 Activity

The eukaryotic elongation factor 1A (eEF1A) delivers aminoacyl-tRNAs to the ribosomal A-site during protein synthesis. To ensure a continuous supply of amino acids, cells harbor the kinase Gcn2 and its effector protein Gcn1. The ultimate signal for amino acid shortage is uncharged tRNAs. We have pro...

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Hauptverfasser: Visweswaraiah, Jyothsna, Lageix, Sebastien, Castilho, Beatriz A., Izotova, Lara, Kinzy, Terri Goss, Hinnebusch, Alan G., Sattlegger, Evelyn
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2011
Schlagworte:
Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3196070/
https://ncbi.nlm.nih.gov/pubmed/21849502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.248898
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