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Overexpression of Eukaryotic Translation Elongation Factor 3 Impairs Gcn2 Protein Activation
In eukaryotes, phosphorylation of translation initiation factor 2α (eIF2α) by the kinase Gcn2 (general control nonderepressible 2) is a key response to amino acid starvation. Sensing starvation requires that Gcn2 directly contacts its effector protein Gcn1, and both must contact the ribosome. We hav...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3488051/ https://ncbi.nlm.nih.gov/pubmed/22888004 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.368266 |
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