Overexpression of Eukaryotic Translation Elongation Factor 3 Impairs Gcn2 Protein Activation

In eukaryotes, phosphorylation of translation initiation factor 2α (eIF2α) by the kinase Gcn2 (general control nonderepressible 2) is a key response to amino acid starvation. Sensing starvation requires that Gcn2 directly contacts its effector protein Gcn1, and both must contact the ribosome. We hav...

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Hlavní autoři: Visweswaraiah, Jyothsna, Lee, Su Jung, Hinnebusch, Alan G., Sattlegger, Evelyn
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3488051/
https://ncbi.nlm.nih.gov/pubmed/22888004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.368266
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