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ADP-ribosylation of Translation Elongation Factor 2 by Diphtheria Toxin in Yeast Inhibits Translation and Cell Separation

Eukaryotic translation elongation factor 2 (eEF2) facilitates the movement of the peptidyl tRNA-mRNA complex from the A site of the ribosome to the P site during protein synthesis. ADP-ribosylation (ADP(R)) of eEF2 by bacterial toxins on a unique diphthamide residue inhibits its translocation activi...

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Detalhes bibliográficos
Main Authors: Mateyak, Maria K., Kinzy, Terri Goss
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3750162/
https://ncbi.nlm.nih.gov/pubmed/23853096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.488783
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