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Translation Elongation Factor 1A Mutants with Altered Actin Bundling Activity Show Reduced Aminoacyl-tRNA Binding and Alter Initiation via eIF2α Phosphorylation

Apart from its canonical function in translation elongation, eukaryotic translation elongation factor 1A (eEF1A) has been shown to interact with the actin cytoskeleton. Amino acid substitutions in eEF1A that reduce its ability to bind and bundle actin in vitro cause improper actin organization in vi...

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Detalhes bibliográficos
Main Authors: Perez, Winder B., Kinzy, Terri Goss
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4110299/
https://ncbi.nlm.nih.gov/pubmed/24936063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.570077
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