Unrestricted Hepatocyte Transduction with Adeno-Associated Virus Serotype 8 Vectors in Mice

Recombinant adeno-associated virus (rAAV) vectors can mediate long-term stable transduction in various target tissues. However, with rAAV serotype 2 (rAAV2) vectors, liver transduction is confined to only a small portion of hepatocytes even after administration of extremely high vector doses. In ord...

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Bibliographic Details

Published in:	J Virol
Main Authors:	Nakai, Hiroyuki, Fuess, Sally, Storm, Theresa A., Muramatsu, Shin-ichi, Nara, Yuko, Kay, Mark A.
Format:	Artigo
Language:	Inglês
Published:	American Society for Microbiology (ASM) 2005
Subjects:	Gene Therapy
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC538708/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15596817/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.79.1.214-224.2005
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