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Adenovirus Early Region 3 Transgenes Expressed in β Cells Prevent Autoimmune Diabetes in Nonobese Diabetic Mice: Effects of Deleting the Adenovirus Death Protein 11.6K

The incidence of type 1 diabetes (T1D) is decreased in nonobese diabetic mice expressing the complete cassette of adenovirus early region 3 (E3) immunomodulating genes in pancreatic β cells. Embedded among the antiapoptotic E3 genes is one encoding an adenovirus death protein (ADP), which contribute...

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Bibliographische Detailangaben
Hauptverfasser: Pierce, Melissa A., Svetlanov, Anton, Horwitz, Marshall S., Serreze, David V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2005
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC538692/
https://ncbi.nlm.nih.gov/pubmed/15596856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.1.619-621.2005
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