Requirement of Fas for the Development of Autoimmune Diabetes in Nonobese Diabetic Mice

Insulin-dependent diabetes mellitus (IDDM) is assumed to be a T cell–mediated autoimmune disease. To investigate the role of Fas-mediated cytotoxicity in pancreatic β cell destruction, we established nonobese diabetic (NOD)-lymphoproliferation (lpr)/lpr mice lacking Fas. Out of three genotypes, fema...

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Detalhes bibliográficos
Main Authors: Itoh, Naoto, Imagawa, Akihisa, Hanafusa, Toshiaki, Waguri, Masako, Yamamoto, Koji, Iwahashi, Hiromi, Moriwaki, Makoto, Nakajima, Hiromu, Miyagawa, Junichiro, Namba, Mitsuyoshi, Makino, Susumu, Nagata, Shigekazu, Kono, Norio, Matsuzawa, Yuji
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 1997
Assuntos:
Brief Definitive Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2199040/
https://ncbi.nlm.nih.gov/pubmed/9254659
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